A circuit model for addiction

Tuesday, December 8th, 2015, 11:00 am
Elmore Auditorium
2015-15 SEMINAR SERIES: Christian Luescher, MD, PhD, University of Geneva
McLean Bolton, PhD
(561) 972-9000

Event Information

Current models of addiction are converging on the idea that aberrant function and remodeling of neural circuits cause the compulsive drug use despite negative consequences that define the disease. According to this hypothesis, drug reward would trigger specific forms of synaptic plasticity, which in susceptible subjects would become persistent. I will test this model by characterising the behaviour and neural changes in mice, which have had the opportunity of self-stimulate VTA dopamine neurons. Several stages from acute reinforcement to cue-associated seeking behaviour and resistance to punishment will be tested. The special emphasis will be on manipulations that allow to establish links of causality.

This seminar is open to faculty, scientists, and students from Max Planck Florida Institute for Neuroscience (MPFI), Florida Atlantic University (FAU), and the Scripps Research Institute Florida, located on FAU’s John D. MacArthur Campus in Jupiter, Florida. If you belong to an institution outside of the Jupiter campus and would like to attend, please send a request to